SpamX: Proactive spam protection available for OS X

One of the most frustrating aspects of spam, besides the sheer idiocy of its existence, is that one often feels powerless to do much about it. Sure, we can try all sorts of desktop solutions and play trial and error trying to train the spam filters, but in the end there is that nagging feeling that you haven't done anything to get at the root of the problem: the spammer.

SpamX is a tool, now available for OS X, that promises not only to stop the flow of viagra offers to your inbox, but to trace spam back to its source and report the offending spammer to their ISP. Now that's a solution! The developer claims most users of the software see their spam levels drop to zero within four weeks, via an undoubtedly more satisfying process of actually targeting the source of the spam.

Does anyone have experience with anti-spam software that works really well? I'm still hunting for the best solution to prevent all those horny housewives from cluttering my inbox. Please specify what email client you use, as well.
Thanks!!