The Daily Grind: Do gender addresses matter?

As a very basic rule of thumb, it seems to be the case that in MMORPGs like World of Warcraft, it's safe to call a person by their real life gender. Males who play MMOs sometimes play them as female avatars, and vice versa. In a virtual world like Second Life, however, the gender of importance belongs to the avatar. The distinction seems to rest on the concept of roleplay.

Obviously it boils down to the player's choice; they decide what they want to be, and how they prefer to be addressed. When they do, if you know the person behind the avatar, do you address them as their avatar's gender, or as their real life gender?